Lesson 6: Carbohydrates

Table of Contents


Introduction

In the last two lessons we discussed protein and fat, the benefits they may or may not confer for dieting and weight loss, the recommended amounts and types for health purposes, and other relevant considerations. In this lesson we will do the same for carbohydrates.

 


Specific considerations for exercise and weight management

Carbohydrate intake can aid glycogen replenishment to provide energy for workouts.(Murray, 2018) For people eating at maintenance calories who are not doing extended cardiovascular sessions this is generally not a significant concern unless training twice within an 8-hour period. For people eating at a caloric deficit it can be harder to replenish glycogen levels effectively to fuel a workout without sufficient carbohydrate intake.

Some people subjectively find consuming carbohydrates prior to a workout allows them to perform their workout with higher intensity. In the protein lesson we discussed timing of protein intake in relation to a workout is not very significant. For carbohydrate intake, though, it can be significant. As different people respond differently, it can take trial and error to determine the best source, quantity, and timing of pre-workout carbohydrates to best fuel a session.

Tip: A “fundamental principal” of a healthy lifestyle including exercise sessions is to make the exercise sessions the best they can be. Being able to train with more focus and intensity will yield better results. For this reason, I recommend trialing a variety of different food/drink items prior to a workout (as well as during a workout) to determine what allows you to train to the best of your ability. Some considerations:

  • Consuming too much food/drink too close to the workout can lead to gastrointestinal discomfort
  • Eating carbohydrates alone will lead to faster digestion than adding a source of protein or fat, which may or may not be helpful
  • Some people do best eating a meal several hours prior to a workout and a small snack shortly before a workout
  • Some people find they train best when fasted
  • If training for >60 minutes it can be helpful to consume a source of carbohydrates during the workout (ie, a sports drink)

This largely comes down to personal preference and experimentation. Try different things and determine what works best for you.

Note: There are people who train while on a ketogenic diet, meaning very little carbohydrate intake, and this has been studied. It is generally shown this can lead to effective cardiovascular adaptations without a negative impact on performance.(McSwiney, 2019) A caveat though is that this is only seen after being “keto-adapted”, meaning one must be on a ketogenic diet for at least several weeks prior to it likely not being detrimental.(Sherrier, 2019) For unclear reasons it seems more difficult to build new lean body mass in response to resistance training while on a ketogenic diet.(Vargas, 2018) I will discuss ketogenic diets further in Lesson 12.


Minimum carbohydrate intake for health purposes

The recommended dietary allowance (“RDA”) for carbohydrate intake at all ages above 1 year old is 130 grams of carbohydrate daily. The acceptable macronutrient distribution range (“AMDR”) is 45-65% of calories.

Note: The RDA was set with the thought that 100 grams of carbohydrate intake daily will provide enough glucose for brain function for ~50% of people; adding two standard deviations to this yields 130 grams. However, we know that many people function well on fewer carbohydrates than this, and those on a ketogenic diet (at times prescribed for medical purposes) generally eat considerably fewer than 50 grams of carbohydrates daily.

The AMDR was set with a limit on the higher range based on data that low fat, high carbohydrates worsened blood cholesterol levels and thus increase the risk of coronary heart disease. The lower limit comes from the thought that low carb, high fat diets will lead to people overeating and increasing their risk of developing obesity.

However, the data used to generate these recommendations is several decades old, and it is now more clear that the source of nutrients rather than just the quantities plays a large role in dictating health outcomes. Therefore, while these recommendations exist and are frequently cited, in my opinion they deserve to be updated.

In light of the above, I do not believe there is a true minimum amount of carbohydrates needed daily; there are technically no essential carbohydrates that the body requires and energy can be generated from fat and protein. However, for health purpose, there are several sources of carbohydrates with health benefits, such as fruits(Fardet, 2019), vegetables(Wallace, 2019), and whole grains(Jones, 2020). A healthy diet including these food sources will require some level of carbohydrate intake. These food groups, and thus sources of carbohydrates, are discussed more fully in Lesson 10.


Maximum carbohydrate intake for health purposes

There are some popular concerns of high carbohydrate diets, such as they will lead to weight gain, diabetes, or high cholesterol. However, there are several studies indicating these concerns are not valid, particularly when the source of carbohydrates are fruits, vegetables, and fiber-rich grains.(Sartorius, 2018; Sylvetsky, 2017) In fact, there is a specific diet, referred to as the Ma-Pi 2 diet, that has shown good outcomes in short term trials on cardiovascular risk factors and glycemic control in adults with type 2 diabetes; in these trials on average 70% of calories came from carbohydrates.(Porrata-Maury, 2014)

Note: I do not actually recommend the Ma-Pi 2 diet as it is difficult to follow, restrictive, and expensive, but I wanted to include it as an example of a very high carbohydrate diet that can yield good outcomes, at least in the short term in adults with type 2 diabetes.

Therefore, the total quantity of carbohydrates one consumes seems less relevant, at least when the food sources are fruits, vegetables, and fiber-rich grains. For this reason, I do not believe there is a true maximum amount of carbohydrates above which one will be at risk of harm, assuming this does not lead to excessive caloric consumption.

 


Consideration of added sugar

The general recommendation for added sugar intake is to limit this to <10% of daily calories. However, this is largely to help ensure there is room for other healthy nutrients while still keeping total calories at a reasonable level as explained by the United States Department of Agriculture and Health and Human Services (USDA-HHS) response to the Dietary Guidelines Advisory Committee’s Report that was used to develop the 2020-2025 Dietary Guidelines for Americans:

"However, after careful consideration of the totality of evidence presented by the Committee, the Dietary Guidelines for Americans, 2020-2025 retains the recommendation to limit intakes of added sugars to less than 10 percent of calories per day in the 2015-2020 Dietary Guidelines. The introduction of this quantitative recommendation was based on significant scientific agreement from data analysis, systematic reviews, and food pattern modeling, and largely, the science has not changed. According to food pattern modeling, the amount of calories available from added sugars varies depending on caloric needs...For those people who need higher calorie intakes per day, an upper limit of 10 percent of calories from added sugars may be consumed while still meeting food group recommendations in nutrient-dense forms.

There are several lines of evidence that added sugar intake above 10% of total daily calories can be safe in individuals who are keeping total caloric intake at a level to obtain/maintain a healthy body weight and exercising regularly.(Rippe, 2015) This extends to considerations of blood pressure, lipids, and glycemic control in some scenarios, though less likely with sugar-sweetened beverages.(Prinz, 2019a; Perrar, 2019;Prinz 2019b) On the other hand, there is a potential increased risk of some cancer types with added sugar intake, although this evidence is epidemiological in nature.(Makarem, 2018) Overall, keeping added sugar at <10% of daily calories is a reasonable goal, though occasionally going over this is unlikely to pose significant health risks.

Note: To be clear, the potential safety of going above 10% daily calories with added sugar depends on this not leading to elevated caloric intake and undesired weight gain. If tracking calories this can be well controlled but if not tracking calories it can be rather difficult to eat substantial amounts of food with added sugar and not start to gain weight. This is in part due to processed foods with added sugar being less satiating than unprocessed whole foods.(Hall, 2019)

Artificial sweeteners as a substitute for added sugar?

While not technically carbohydrates, artificial sweeteners are frequently used as a substitute for added sugar and thus they are worth discussing here. This is a controversial topic; at this point the majority of the literature suggests that artificial sweeteners can be used safely in moderation. For an overview of the research on this topic, click below.

Artificial sweeteners, also referred to as low-calorie sweeteners (“LCS”) and non-nutritive sweeteners (“NNS”), pose yet another controversial topic in the literature, primarily regarding their impact on body weight as well as glucose and insulin control. I will discuss some of the more recent literature here.

Some select 2018 references:

  • In a 12 week trial, 100 healthy adults with BMI 18-25 and low habitual consumption of LCS were split into 3 groups (control, 350mg of aspartame daily (equivalent to ~1 can of low calorie soda), and 1050mg of aspartame daily).(Higgins, 2018) An oral glucose tolerance test (OGTT) conducted before and after the 12 week period showed no differences in glucose or insulin response, and there were additionally no differences in weight or appetite.
  • In a 14 day trial, 30 healthy adults with normal BMI and low habitual consumption of LCS were given ~45% of the acceptable daily intake for sucralose divided into 3 doses daily.(Romo-Romo, 2018) With an OGTT blood glucose response did not change but insulin sensitivity decreased 17.7% after the trial (a control group had a decrease of 2.8%).
  • A review highlights some of the harmful effects of LCS on weight control and metabolic diseases seen in epidemiological studies and contrasts this with the neutral or even beneficial effects seen in controlled trials, indicating longer, well-controlled intervention studies are needed.(Sylvetsky, 2018)

Some select 2019 references:

  • A policy statement by the American Academy of Pediatrics regarding LCS in children and adolescents also acknowledges the literature is conflicting, there may be reverse causality explaining some of the negative associations seen in observational literatures, and trials indicate artificial sweeteners can have positive benefits for weight management.(Baker-Smith, 2019)
  • In a 12 week trial, 123 healthy adults with BMI 25-40 who were not habitual consumers of LCS at baseline were randomly assigned into 5 groups.(Higgins, 2019) One group was given a beverage to drink daily consisting of sucrose (sugar); the volume was based on the individual’s body weight and the beverages had either 400, 480, or 560 kcals. The other four groups were given beverages without sucrose that had sweetness matched with one of four tested LCS (saccharin, aspartame, rebA, sucralose). There was more body weight gain with sucrose (1.85kg) than with any of the artificial sweeteners (1.18kg for saccharin, no significant gain in the other groups). There were no differences in fasting glucose, fasting insulin, or glucose & insulin responses to an OGTT before or after the intervention.

Some select 2020 references:

  • This systematic review & meta-analysis of human intervention studies investing the acute effect of LCS on postprandial glucose & insulin responses finds they collectively have no impact.(Greylink, 2020) A commentary highlights some of the methodological issues that have plagued the observational and intervention studies previously and shows there are several planned & ongoing trials and systematic reviews & meta-analyses which will address some of this ambiguity.(Khan, 2020)
  • A review specifically evaluates the impact of aspartame & sucralose (two of the most commonly used LCS) on glucose responses and gut hormones (these are implicated in appetite control).(Ahmad, 2020) They find most studies show no impact of the LCS but a small handful show positive or negative effects, and they highlight more research with better designed protocols is needed.
  • In a 2 week trial, 45 adults without obesity and with low habitual consumption of LCS were split into 3 groups, each consuming a drink 7 times in a 2 week time span.(Dalenberg, 2020) The drinks either contained 120 kcal of sucrose, the LCS sucralose (in an amount to match sweetness with the sucrose beverage), or a combination of maltodextrin (a non-sweet carbohydrate) and sucralose (also to match sweetness of the sucrose beverage. They subsequently added a control group with maltodextrin only. Brain scans as well as an OGTT and other testing were done before and after the 2 week intervention. They find worsening insulin metrics with the maltodextrin + sucralose drink than with either sucrose, sucralose, or maltodextrin alone. This suggests that consuming sucralose without a source of carbohydrate may not be harmful but consuming sucralose with carbohydrate may worsen insulin sensitivity. Given the short intervention and the small number of subjects this needs to be replicated on a larger scale.

Recommendations:

Most of the better done research (from a methodology perspective) thus far does not observe a negative impact of LCS on body weight control or glucose and insulin levels in the body. However, the last study mentioned above does show a potential concern, and it’s possible that many of the prior studies were not designed to find it since this study did not find a concern with LCS alone (which is commonly studied) but did find a concern with maltodextrin + LCS (not commonly studied). On the other hand, the trial was very small. As indicated in the commentary cited above, several more studies are in the pipeline, many of which will do a better job addressing the methodological limitations seen thus far. Until then it is difficult to draw concrete solutions, but at this point in time if using products with LCS in moderation in lieu of actual sugar permits one to better stick to an overall healthy eating plan and caloric goal then I believe this is a reasonable strategy.


Consideration of the glycemic index and glycemic load

While the body can perhaps handle increased amounts of added sugar when keeping total calories in a healthy range, another consideration is if the added sugar is consumed all at once in a rapidly digesting form (ie, a sugar-sweetened beverage) or spread out in meals that slow down the digestion. This gets into the notion of glycemic index and glycemic load:

  • glycemic index: this is defined as the area under the curve for blood glucose response over a 2 hour period after feeding a 50 gram carbohydrate portion of both a test food and a standard food (50 gram glucose or 50 gram carbohydrate portion of white bread) and expressing the data as a percentage of the test food relative to the standard food
  • glycemic load: this takes portion size into account; the glycemic index for a food is multiplied by the quantity of carbohydrates and divided by 100

                      

There are several considerations here:

  • First, when calculating glycemic index values there is both interindividual variability (testing the same food item on different people) and intraindividual variability (replicating the test in the same individual), with one study showing coefficients of variation of 17.8% (interindividual) and 42.8% (intraindividual) when testing white bread in triplicate relative to glucose.(Vega-López, 2007)
  • Second, while the glycemic index technically should be tested in the morning after an overnight fast, when eating throughout the day prior meals can impact and hence alter glycemic responses of the current meal being consumed.(Ando, 2018)
  • Third, based on other real world conditions (as opposed to lab-testing conditions) and interindividual variability, specific meals may generate improved glycemic responses in some individuals while the same meals may generate worsened glycemic responses in others.(Zeevi, 2015)

For these reasons, it is not very surprising that the totality of evidence does not indicate significant health implications of the glycemic index or glycemic load, with large systematic reviews and meta-analyses indicating no overly significant impact on body weight, diabetes, cardiovascular disease, cancer, or all-cause mortality.(Vega-López, 2018; Turati, 2019; Reynolds, 2019)



Conclusion

Overall, much of dietary carbohydrate intake comes down to personal preference. Some people feel better and perform better with higher carbohydrate diets while some people prefer lower carbohydrate diets. Indeed, the literature as a whole does not generally suggest a preference for low carb/high fat vs high carb/low fat with regards to weight management.(Seid, 2019) Trial and error helps to determine what works best for any given individual, particularly with regards to pre-workout nutrition. Fruits, vegetables, and whole grains with fiber all have several beneficial health properties and these sources of carbohydrates should be prioritized if sticking to lower carbohydrate intakes. If consuming higher intakes, limiting added sugar to <10% of total daily calories is the safest option, though less worrisome if one maintains a healthy body weight and exercises regularly. Sugar-sweetened beverages should in particular be avoided, especially when consumed in isolation.

As we have now discussed the three primary macronutrients, in the next two lessons we will discuss fiber and alcohol.

Click here to proceed to Lesson 7


References

  1. Ahmad SY, Friel JK, Mackay DS. Effect of sucralose and aspartame on glucose metabolism and gut hormones. Nutr Rev. 2020 Sep 1;78(9):725-746. doi: 10.1093/nutrit/nuz099. PMID: 32065635.
  2. Ando T, Nakae S, Usui C, et al. Effect of diurnal variations in the carbohydrate and fat composition of meals on postprandial glycemic
    response in healthy adults: a novel insight for the second-meal phenomenon. Am J Clin Nutr. 2018;108(2):332-342. doi:10.1093/ajcn/nqy086
  3. Baker-Smith CM, de Ferranti SD, Cochran WJ; COMMITTEE ON NUTRITION, SECTION ON GASTROENTEROLOGY, HEPATOLOGY, AND NUTRITION. The Use of Nonnutritive Sweeteners in Children. Pediatrics. 2019 Nov;144(5):e20192765. doi: 10.1542/peds.2019-2765. PMID: 31659005.
  4. Dalenberg JR, Patel BP, Denis R, Veldhuizen MG, Nakamura Y, Vinke PC, Luquet S, Small DM. Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans. Cell Metab. 2020 Mar 3;31(3):493-502.e7. doi: 10.1016/j.cmet.2020.01.014. PMID: 32130881.
  5. Fardet A, Richonnet C, Mazur A. Association between consumption of fruit or processed fruit and chronic diseases and their risk factors: a systematic review of meta-analyses. Nutr Rev. 2019;77(6):376-387. doi:10.1093/nutrit/nuz004
  6. Greyling A, Appleton KM, Raben A, Mela DJ. Acute glycemic and insulinemic effects of low-energy sweeteners: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2020 Oct 1;112(4):1002-1014. doi: 10.1093/ajcn/nqaa167. PMID: 32672338.
  7. Hall KD, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen KY, Chung ST, Costa E, Courville A, Darcey V, Fletcher LA, Forde CG, Gharib AM, Guo J, Howard R, Joseph PV, McGehee S, Ouwerkerk R, Raisinger K, Rozga I, Stagliano M, Walter M, Walter PJ, Yang S, Zhou M. Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake. Cell Metab. 2020 Oct 6;32(4):690. doi: 10.1016/j.cmet.2020.08.014. Erratum for: Cell Metab. 2019 Jul 2;30(1):67-77.e3. PMID: 33027677.
  8. Higgins KA, Considine RV, Mattes RD. Aspartame Consumption for 12 Weeks Does Not Affect Glycemia, Appetite, or Body Weight of Healthy, Lean Adults in a Randomized Controlled Trial. J Nutr. 2018 Apr 1;148(4):650-657. doi: 10.1093/jn/nxy021. PMID: 29659969.
  9. Higgins KA, Mattes RD. A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. Am J Clin Nutr. 2019 May 1;109(5):1288-1301. doi: 10.1093/ajcn/nqy381. PMID: 30997499.
  10. Jones JM, García CG, Braun HJ. Perspective: Whole and Refined Grains and Health-Evidence Supporting “Make Half Your Grains Whole”. Adv Nutr. 2020;11(3):492-506. doi:10.1093/advances/nmz114
  11. Khan TA, Sievenpiper JL. Low-energy sweeteners and cardiometabolic health: is there method in the madness? Am J Clin Nutr. 2020 Oct 1;112(4):917-919. doi: 10.1093/ajcn/nqaa260. PMID: 32936875.
  12. Makarem N, Bandera EV, Nicholson JM, Parekh N. Consumption of Sugars, Sugary Foods, and Sugary Beverages in Relation to Cancer Risk: A Systematic Review of Longitudinal Studies. Annu Rev Nutr. 2018;38:17-39. doi:10.1146/annurev-nutr-082117-051805
  13. McSwiney FT, Doyle L, Plews DJ, Zinn C. Impact Of Ketogenic Diet On Athletes: Current Insights. Open Access J Sports Med. 2019;10:171-183. Published 2019 Nov 15. doi:10.2147/OAJSM.S180409
  14. Murray B, Rosenbloom C. Fundamentals of glycogen metabolism for coaches and athletes. Nutr Rev. 2018;76(4):243-259. doi:10.1093/nutrit/nuy001
  15. Perrar I, Alexy U. Comments on: “The role of dietary sugars in health: molecular composition or just calories?”. Eur J Clin Nutr. 2019;73(9):1323-1324. doi:10.1038/s41430-019-0456-3
  16. Porrata-Maury C, Hernández-Triana M, Ruiz-Álvarez V, et al. Ma-Pi 2 macrobiotic diet and type 2 diabetes mellitus: pooled analysis of short-term intervention studies. Diabetes Metab Res Rev. 2014;30 Suppl 1:55-66. doi:10.1002/dmrr.2519
  17. Prinz P. The role of dietary sugars in health: molecular composition or just calories?. Eur J Clin Nutr. 2019a;73(9):1216-1223. doi:10.1038/s41430-019-0407-z
  18. Prinz P. Author’s reply to: Comments on “The role of dietary sugars in health: molecular composition or just calories?”. Eur J Clin Nutr. 2019b;73(9):1325-1326. doi:10.1038/s41430-019-0457-2
  19. Reynolds A, Mann J, Cummings J, Winter N, Mete E, Te Morenga L. Carbohydrate quality and human health: a series of systematic reviews
    and meta-analyses [published correction appears in Lancet. 2019 Feb 2;393(10170):406]. Lancet. 2019;393(10170):434-445. doi:10.1016/S0140-6736(18)31809-9
  20. Rippe JM, Angelopoulos TJ. Sugars and Health Controversies: What Does the Science Say?. Adv Nutr. 2015;6(4):493S-503S. Published 2015 Jul 7. doi:10.3945/an.114.007195
  21. Romo-Romo A, Aguilar-Salinas CA, Brito-Córdova GX, Gómez-Díaz RA, Almeda-Valdes P. Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial. Am J Clin Nutr. 2018 Sep 1;108(3):485-491. doi: 10.1093/ajcn/nqy152. PMID: 30535090.
  22. Sartorius K, Sartorius B, Madiba TE, Stefan C. Does high-carbohydrate intake lead to increased risk of obesity? A systematic review and meta-analysis. BMJ Open. 2018;8(2):e018449. Published 2018 Feb 8. doi:10.1136/bmjopen-2017-018449
  23. Seid H, Rosenbaum M. Low Carbohydrate and Low-Fat Diets: What We Don’t Know and Why we Should Know It. Nutrients. 2019 Nov 12;11(11):2749. doi: 10.3390/nu11112749. PMID: 31726791; PMCID: PMC6893678.
  24. Sherrier M, Li H. The impact of keto-adaptation on exercise performance and the role of metabolic-regulating cytokines. Am J Clin Nutr. 2019;110(3):562-573. doi:10.1093/ajcn/nqz145
  25. Sylvetsky AC, Edelstein SL, Walford G, et al. A High-Carbohydrate, High-Fiber, Low-Fat Diet Results in Weight Loss among Adults at High Risk of Type 2 Diabetes. J Nutr. 2017;147(11):2060-2066. doi:10.3945/jn.117.252395
  26. Sylvetsky AC, Rother KI. Nonnutritive Sweeteners in Weight Management and Chronic Disease: A Review. Obesity (Silver Spring). 2018 Apr;26(4):635-640. doi: 10.1002/oby.22139. PMID: 29570245; PMCID: PMC5868411.
  27. Turati F, Galeone C, Augustin LSA, La Vecchia C. Glycemic Index, Glycemic Load and Cancer Risk: An Updated Meta-Analysis. Nutrients. 2019;11(10):2342. Published 2019 Oct 2. doi:10.3390/nu11102342
  28. Vargas S, Romance R, Petro JL, et al. Efficacy of ketogenic diet on body composition during resistance training in trained men: a randomized controlled trial. J Int Soc Sports Nutr. 2018;15(1):31. Published 2018 Jul 9. doi:10.1186/s12970-018-0236-9
  29. Vega-López S, Ausman LM, Griffith JL, Lichtenstein AH. Interindividual variability and intra-individual reproducibility of glycemic index
    values for commercial white bread. Diabetes Care. 2007;30(6):1412-1417. doi:10.2337/dc06-1598
  30. Vega-López S, Venn BJ, Slavin JL. Relevance of the Glycemic Index and Glycemic Load for Body Weight, Diabetes, and Cardiovascular Disease. Nutrients. 2018;10(10):1361. Published 2018 Sep 22. doi:10.3390/nu10101361
  31. Wallace TC, Bailey RL, Blumberg JB, et al. Fruits, vegetables, and health: A comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake [published online ahead of print, 2019 Jul 3]. Crit Rev Food Sci Nutr. 2019;1-38. doi:10.1080/10408398.2019.1632258
  32. Zeevi D, Korem T, Zmora N, et al. Personalized Nutrition by Prediction of Glycemic Responses. Cell. 2015;163(5):1079-1094. doi:10.1016/j.cell.2015.11.001
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